Programs of Study

Back to Program List

Biochemistry (PhD)

Download the Program description (in PDF)

General
Information

Teaching
Staff

Admission

Program
Requirements

Courses

Contact
Us

The Department of biochemistry, microbiology and immunology located in the Faculty of Medicine offers graduate programs leading to the master’s (MSc) and doctoral (PhD) degrees in Biochemistry.

The objective of the program is to prepare candidates for a career in university teaching and research. Graduate students are actively involved in laboratory research, course work, and presentation of research seminars. Thus, they acquire autonomy in conducting research and in preparing publications. The program creates a stimulating and challenging environment which will allow students to achieve excellence in research. Graduates of the program must demonstrate research skills and credibility as professionals in their area of research.

Members of the Department are involved in three main research fields: general biochemistry, molecular biology, and, nutrition and metabolism. Further information is posted on the departmental website.

The Department is a participating unit in the collaborative programs in bioinformatics (at the master’s level), in human and molecular genetics (at the master’s and doctoral levels), and in pathology and experimental medicine (at the master's and doctoral levels).

Most of the courses in these programs are offered in English. Research activities can be conducted either in English, French or both, depending on the language used by the professor and the members of his or her research group.

In accordance with the University of Ottawa regulation, students have a right to produce their work, their thesis, and to answer examination questions in French or in English.

The programs operate within the general framework of the general regulations of the Faculty of Graduate and Postdoctoral Studies (FGPS) of the University of Ottawa, which are posted on the FGPS website.

Search all research fields for members of the teaching staff

The professors included in the list below are members of the Faculty of Graduate and Postdoctoral Studies. This means that they are authorized to supervise or co-supervise theses. A complete list of the faculty and staff members associated with the program can be found at http://www.med.uottawa.ca/grad/eng/departments.html

ADDISON, Christina, Cross-appointment
Angiogenisis; cancer; extracellular matrix

ALTOSAAR, Illimar, Full Professor
Biotech foods as global medicines

BAENZIGER, John, Full Professor
Nicotinic receptors; membrane proteins; structure/function; crystallization; biophysics; lipid-protein interactions

BAETZ, Kristin, Full Professor
Functional genomics

BASAK, AJOY, Cross-appointment
Proteolytic enzymes;inhibitor; peptide chemistry; peptide hormones; protein aggregation; dementia

BELL, John, Cross-appointment
Ocolytic viruses; protein translation; cancer therapeutics

BENNETT, Steffany, Associate Professor
Neuroregeneration; degeneration; apoptosis; stem cells; Gap junctions; Alzheimer's; transgenic mouse models

BICKEL, David, Cross-appointment
Statistical bioinformatics: gene expression data analysis; molecular network reconstruction; model validation methodology; Bayesian and empirical Bayes inference; machine learning algorithms; and Monte Carlo simulation

BIRNBOIM, Hyman, Cross-appointment

BLAIS, Alexandre
Our lab studies the six family of transcription factors and the critical role its members play in muscle development; we are interested in understanding, at the molecular level, the mode of action of these transcription factors

BOYCOTT, Kym Marie, Cross-appointment

BULMAN, Dennis, Cross-appointment
Human genetics; linkage analysis; disease gene identification; myoclonus dystonia; Parkinson's; brachydactyly

CHAKRABORTY, Pranesh

CHENG, Mary, Assistant Professor
Understanding the body's biological clock on a highly detailed genetic level

CHRÉTIEN, Michel, Cross-appointment
Neural and hormonal peptides; proprotein convertases; atherosclerosis; diabetes; Alzheimer'

COCKELL, Kevin, Adjunct Professor
Nutrition; mineral nutrients; metabolic interactions

COUTURE, Jean-François, Assistant Professor
Genetic information is packaged into a chromatin polymer which must be opened to increase the accessibility of gene regulatory factors, or compacted to restrict the access of the transcriptional machinery to target genes

DIMITROULAKOS, Jim, Cross-appointment
Experimental therapeutics; cancer; targeted therapy

FAIRHEAD, Todd, Cross-appointment

FIGEYS, Daniel, Full Professor
Proteomics technology and applications in systems biology

GARBER, Gary, Cross-appointment
Trichomonas vaginalis; vaginitis; sepsis; vaccine development; mouse models

GRAY, Douglas, Cross-appointment
Proteins inside cells are normally degraded through elaborate and highly regulated cellular machinery; and failure to do so underlies many disease states, we are studying the role of protein degradation in neurodegenerative diseases; lung cancer and aging; these conditions are studied using transgenic mice

HARPER, Mary-Ellen, Full Professor
Mitochondrial energetics; uncoupling proteins; metabolic regulation; obesity and diabetes

HEFFORD, Mary Alice, Adjunct Professor

HOLCIK, Martin, Cross-appointment
Apoptosis; cancer; IAP; translational control; RNA binding proteins; signal transduction

HOU, Sheng T., Adjunct Professor
Neurodegeneration; regeneration; apoptosis; axonal guidance; stroke

IOSHIKHES, Ilya, Associate Professor
Transcriptional regulation of gene expression; nucleosome positioning as essential element of gene regulation, micro-RNA regulation.

KUROSKI DE BOLD, Mercedes L, Cross-appointment

LABOW, Rosalind, Cross-appointment
Biomaterials; cell signaling in macrophages on material surfaces during tissue regenerations

LAGACE, Thomas, Cross-appointment
Atherosclerosis, Genetics and Cell Biology; Lipoprotein Receptor Biology

LANEUVILLE, Odette, Full Professor
Understanding the regulation of expression of the enzyme cyclooxygenase

LEE, Hoyun, Cross-appointment
Cell cycle control; DNA replication; cancer research

LIU, Qing Yan, Adjunct Professor
Molecular genetics; genomics; apoptosis; neurodegeneration; DNA microarray; bioinformatics

LIU, Xingquan Johne, Adjunct Professor
Hormonal regulation of egg maturation; nongenomic action of progesterone in the Xenopus oocyte

LORIMER, Ian A.J., Cross-appointment
Cancer therapeutics targeting a mutant oncogenic EGF receptor

MACFARLANE, Amanda, Adjunct Professor
Folic acid metabolism; Inflammation and cancer; Fetal origins of disease; Epigenetics

MACKENZIE, Alexander, Cross-appointment
Spinal muscular atrophy (SMA); role of neuronal apoptosis inhibitory peptide

MACPHERSON, Paul, Cross-appointment
Effects of the HIV Tat protein on IL-7 receptor expression on CD8 T-cells; terminal differentiation of CD8 T-cells in HIV infected patients; IL-7 receptor expression in HIV+ patients with slow or nonprogressive disease, transcriptional regulation of the IL-7 receptor in CD8 T-cells

MBIKAY, Majambu, Cross-appointment
Obesity & diabetes; infertility

MCBURNEY, Michael, Cross-appointment
Molecular basis of gene silencing in mammalian cells

MCPHERSON, Phyllis, Cross-appointment
Regulation of HDL receptors; cholesterol trafficking, atherothrombotic risk

MEZL, Vasek, Associate Professor
Vitamin E (-tocopherol); regeneration of Vitamin E

MILNE, Ross, Cross-appointment
Features of the LDL receptor and of lipoproteins that allow them to specifically recognize each other and interact

NEMER, Mona, Full Professor
Molecular mechanisms involved in cellular growth and differentiation, particularly as this relates to heart failure and congenital heart diseases

PELCHAT, Martin
Host components involved in subviral RNA pathogen replication

PERKINS, Theodore, Assistant Professor

PEZACKI, John P., Adjunct Professor
Biology and Virology Research

RUDNER, Adam, Assistant Professor
Chromosome structure and dynamics; yeast genetics; cell cycle regulation

SCOTT, Fraser, Full Professor
Nutritional modification of type 1 autoimmune diabetes; bioactive food components

SKERJANC, Ilona, Full Professor
Cardiac and sketetal muscle development; stem cells; gene expression

SORISKY, Alexander, Cross-appointment
Obesity; adipocyte differentiation; insulin action; apoptosis; diabetes

SPARKS, Daniel, Cross-appointment
The role of high density lipoprotein charge and structure in the metabolism of cholesterol

STEWART, Alexandre, Cross-appointment
Inherited cardiovascular disorders; genetic risk factors for Coronary Artery Disease

TANPHAICHITR, Nongnuj, Cross-appointment
Mammalian reproduction; contraceptives; fertilization; reproductive toxicology and biotechnology

TESSON, Frédérique, Cross-appointment
Idiopathic dilated cardiomyopathy, genetic predictors of weight loss in obese women

TRUDEL, Guy, Full Professor

WOULFE, John, Cross-appointment
Neurodegenerative dementias; (Alzheimer's disease and non-Alzheimer's frontotemporal dementias); Parkinson's disease and the synucleinopathies; pathogenesis of certain neurodegenerative disorders

YAO, Zemin, Full Professor
Factors required for hepatic assembly and secretion of apoB-containing lipoproteins; the LDL-receptor binding domain(s) within human apoB100; mechanisms responsible for the intracellular degradation of newly synthesized apoB, Structure/function relationships within LRP (the LDL-receptor Related Protein) and its potential role in post-prendial fat absorption by the adipose tissue

ZHA, Xiaohui, Cross-appointment
Fluorescent microscopy; membrane trafficking; cholesterol

Admission to the graduate program in Biochemistry is governed by the general regulations of the FGPS.

To be considered for admission, applicants must:

Hold a master's degree in science (or equivalent) with a minimum average of 75% (B+).
Demonstrate aptitude for research either through completion of a master's degree, or the writing of research reports, or abstracts or other documents demonstrating research skills.
Provide at least two confidential letters of recommendation from professors who have known the applicant and are familiar with their work.
Provide a statement of purpose indicating their academic interests, career goals and other factors relevant to their choice of research area.
Identify at least one professor who is willing and available to act as thesis supervisor.
Be proficient (understand, speak and write) in English. Most of the courses in these programs are offered in English. Research activities can be conducted either in English, French or both, depending on the language used by the professor and the members of his or her research group.

The Department may require students to take additional courses depending on their backgrounds.

Transfer from Master’s to PhD Program

Outstanding students enrolled in the MSc program may be allowed to transfer to the PhD program without being required to write a master’s thesis provided they meet the following conditions:

Maintain an A- average during their graduate studies and in the last two years of undergraduate studies.
Complete all the core courses required for the M.Sc.
Demonstrate a satisfactory progress in the research program.
Provide a written recommendation by the thesis supervisor.
Provide a written recommendation by the Departmental Graduate Studies Committee.

The transfer must take place within sixteen months of initial registration in the master’s. Please note that the minimal admission average requirements for the doctoral program must also be met. Following transfer, all of the requirements of the doctoral program must be met: the doctoral seminar courses (BCH8366), six credits of course work (from BCH8000 level courses), the comprehensive exam (BCH9998), a research seminar (BCH9997) and the thesis (BCH9999).

Collaborative Program in Human and Molecular Genetics at the Master's and Doctorate Levels

The Department of Biochemistry, Microbiology and Immunology is a participating unit in the collaborative program in Human and Molecular Genetics at the master’s and doctorate levels. Students should indicate in their initial application for admission that they wish to be accepted into this program. The thesis director must be a member of the collaborative program. For further details, see the description of the Human and Molecular Genetics program posted on the FGPS website.

Collaborative Program in Pathology and Experimental Medicine at the Master's and Doctorate Levels

The Department of Biochemistry, Microbiology and Immunology is a participating unit in the collaborative program in Pathology and Experimental Medicine at the master’s and doctorate levels. Students should indicate in their initial application for admission that they wish to be accepted into this program. The thesis director must be a member of the collaborative program. For further details, see the description of the Pathology and Experimental Medicine program posted on the FGPS website.

Biochemistry PhD

The requirements for the PhD in Biochemistry are as follows:

Successful completion of compulsory course MED8166 Professionalism and Professional Skills.

Six credits from BCH 8000 level courses or from other approved graduate courses in related disciplines approved by the Department.

Enrolment in the seminar course BCH8366, which involve the presentation of a seminar and regular attendance at the departmental seminars.

Presentation of a seminar based on original research (BCH9997).

Successful completion of a comprehensive examination (BCH9998).

Presentation and defense of a thesis (BCH9999) based on original research carried out under the direct supervision of a faculty member of the Department.

The passing grade in all courses is B. Students who fail two courses (equivalent to 6 credits), the thesis proposal, or the comprehensive exam or whose research progress is deemed unsatisfactory are required to withdraw.

NOTE: The Department may require students to take additional courses depending on their backgrounds.

Collaborative Program in Human and Molecular Genetics

The student is responsible for fulfilling both the participating unit requirements for the primary program and the requirements for the collaborative program.

Six credits of courses, three credits of which must be from the student’s primary program and three of which must be HMG credits.

Enrolment in the seminar course, presentation of one seminar and active participation in the seminar series in the student’s primary program.

Comprehensive examination as required by the primary program.

Presentation of one research seminar to the primary program prior to thesis submission.

Presentation and successful defence of a thesis based on original research carried out under the direct supervision of a member of the collaborative program.

The passing grade in all courses is C+. Students who fail two courses (equivalent to 6 credits), the thesis proposal, or the comprehensive exam or whose research progress is deemed unsatisfactory are required to withdraw.

Course selection is subject to the approval of the HMG program director.

Collaborative Program in Pathology and Experimental Medicine

The requirements of both the primary program and those of the collaborative program must be met.

The requirements specific to the collaborative program are as follows:

One course (3 credits) in the primary program.

One Pathology and Experimental Medicine specialization course (3 credits).

Successful completion of the Pathology and Experimental Medicine seminar course.

Successful completion of the Comprehensive Examination as required by the respective primary program.

Preparation and defense of a thesis under the supervision of a professor who is a member of the Pathology and Experimental Medicine program. The thesis must be relevant to the focus of the Pathology and Experimental Medicine program. At least one of the examiners must be a member of the Pathology and Experimental Medicine collaborative program.

Duration of the Program

The requirements of the program are usually fulfilled within four years. The maximum time permitted is six years from the date of initial registration in the program, or seven years in the case of the students transferring from the master’s to the doctorate.

Residence

All students must complete a minimum of six sessions of full-time registration. In the case of transfer students, the residency period is nine full-time sessions from the initial date of registration in the master's program.

Thesis Advisory Committee

During the first session of the program, a thesis advisory committee (TAC) is formed for the candidate. The Committee’s membership will be determined by the specific interests of the candidate. It will be composed of the supervisor and 2-3 additional professors. At least one member of the thesis committee, in addition to the supervisor, must be form the Faculty of Medecine. The TAC is responsible for guiding the student throughout the program, including course selection, the comprehensive examination, thesis proposal, and thesis defense.

The thesis examining board may include members who are not part of the TAC.

Tous les cours ne sont pas nécessairement offerts chaque année. Les cours sont offerts dans la langue dans laquelle ils sont décrits.

Not all of the listed courses are given each year. The course is offered in the language in which it is described.

BCH5101 ANALYSIS OF –OMICS DATA (3cr.)
Theoretical and practical aspects of various methods currently used to analyze the plethora mountain of –omics data. Methods: sequence alignment and database searches; sequence analysis and bioinformatics of gene regulation; DNA microarray and sequencing technologies to identify transcription factor binding sites; analysis of proteomics data; statistical analysis of preprocessed gene expression and protein/metabolite abundance data; epidemiology applications. Critical reading of the literature and strategies for making informed choices of methods for the analysis of students’ own data. Prerequisites: BCH2333, BCH3170.

BCH5366 MSc SEMINAR (3cr.)
Attendance and participation in the annual BMI Student Symposium and BMI Poster Day, attendance at BMI seminars relevant to Biochemistry. Students must present at least one poster and one oral presentation during the course of their program. Graded S/NS

BCH5501 ANALYSE DES DONNÉES –OMIQUES (3cr.)
Les aspects théoriques et pratiques des méthodes actuellement utilisées pour l’analyse des données –omiques. Méthodes : alignement des séquences et recherche dans les bases de données; analyse des séquences et bioinformatique de l’expression génique; micro puces d’ADN et technologies de séquençage utilisées pour l’identification des sites de liaison des facteurs de transcription; l’analyse des données protéomiques; l’analyse statistique de l’expression génique prétraitée; et applications aux données protéine/abondance de métabolites, épidémiologie. Lecture critique de la littérature et stratégies pour faire des choix informés quant à la sélection des méthodes pour l’analyse des données. Préalables : BCH2333, BCH3170.

BCH7999 RECHERCHE POUR LA THÈSE DE MAÎTRISE / MSC THESIS RESEARCH
À l'intention des étudiants faisant de la recherche en vue de l'obtention de la maîtrise. Les étudiants doivent soumettre au Département un plan détaillé de la recherche qu'ils se proposent de faire. Chaque année une rencontre avec un comité consultatif doit avoir lieu et un rapport de progrès doit être soumis au Département. / For students doing research leading to the MSc degree. Students are responsible for ensuring that a detailed outline of the proposed research is on file with the Department and that they have an annual meeting with an advisory committee. Yearly progress reports must also be submitted to the Department.

BCH8101 PHYSICAL AND CHEMICAL METHODS IN BIOCHEMISTRY (3cr.)
Current applications of physical and chemical methods to the study of macromolecule structure-function relationships.

BCH8102 SELECTED TOPICS IN PROTEIN STRUCTURE AND FUNCTION (3cr.)
An advanced study of recent literature dealing with structure-function relationships in selected proteins.

BCH8103 / MIC 8228 ADVANCED TOPICS IN GENE EXPRESSION AND PROTEIN SYNTHESIS (3cr.)
An advanced study of the recent literature dealing with the chemistry, metabolism and function of nucleic acids, the biosynthesis of proteins, biochemical and genetic control mechanisms, genetic engineering and the control of gene expression. Offered every second year in alternation with MIC 8227/BCH 8105. Prerequisite: BPS 4101 or equivalent with the permission of the instructor.

BCH8104 ADVANCED TOPICS IN CELL REGULATION (3cr.)
An advanced study of recent literature dealing with signal transduction processes and the regulation of metabolism, cell proliferation and differentiation.

BCH8105 / MIC 8227 ADVANCED TOPICS IN MOLECULAR BIOLOGY OF HUMAN DISEASES (3cr.)
Topics will be selected and representative of current developments in the field. The course consists of a repeated series of a 3 hour lecture by an expert in the field one week, followed by student presentations, discussions and critique of assigned papers on that topic the following week. Topics on selected diseases will focus on various aspects of cancer, apoptosis, disease gene identification and gene therapy. In the past these topics have included the molecular aspects of various cancers, spinal muscular atrophy, tissue regeneration, the discovery of disease genes, infectious disease (HIV) and gene therapy. Students will write a grant proposal and participate in mock grant review panels. Depending on enrolment, the course may be limited to HMG students only. Prerequisite: Permission of the HMG program director.

BCH8106 ADVANCED TOPICS IN NUTRITION AND REGULATION OF METABOLISM (3cr.)
An advanced study of the recent literature dealing with metabolism, nutrition and metabolic control theory, with emphasis on both whole body and cell metabolism in metabolic and nutritional disorders such as obesity and non-insulin-dependent diabetes mellitus (NIDDM).

BCH8107 ADVANCED TOPICS IN STRUCTURE AND FUNCTION OF PLASMA LIPOPROTEINS (3cr.)
Recent advances in our knowledge of the plasma lipoproteins with a special emphasis on their role in the etiology of atherosclerosis. The subject will be introduced by an overview of the general structural properties of lipoproteins which will be followed by detailed discussion of the structure, metabolism and genetics of the apolipoproteins, the proteins and enzymes that modify lipoproteins and cell surface lipoprotein receptors. Other topics will include cholesterol homeostasis, plasma cholesterol transport and disorders of lipoprotein metabolism.

BCH8108 ADVANCED METHODS OF MACROMOLECULAR STRUCTURE DETERMINATION (3cr.)
A detailed examination of modern methods used to determine the structures of proteins, nucleic acids, and carbohydrates. May include X-ray crystallography, electron diffraction, nuclear magnetic resonance, and other spectroscopic methods.

BCH8109 / MIC 8124 ADVANCED TOPICS IN CELL DEATH (3cr.)
Molecular mechanisms of cell death. Particular attention to be paid to role of aberrant cell death in human disease. Offered in the Fall of odd numbered years.

BCH8110 ADVANCED TOPICS IN SYSTEMS BIOLOGY (3cr.)
Recent advances in genomics, proteomics, bioinformatics, and neuroinformatics including functional and chemical genomics, RNA analyses, microarrays, mass spectrometry, and neural imaging. Course requirements include student presentations and writing a mock research proposal based on Canadian Institutes of Health Research (CIHR) guidelines. Limited enrollment. Offered in alternate years with BCH 8101 Physical and Chemical Methods in Biochemistry. Prerequisite: Permission of the program director.

BCH8111 CHROMOSOME AND CHROMATIN BIOLOGY (3cr.)
Higher order chromosome structure and chromatin remodeling and their impact on regulation of gene expression, DNA replication, repair and recombination, and chromosome segregation. Histone modifications and nucleosome positioning and their influence on higher order chromosome structure. Importance of chromosome and chromatin in the context of the cell cycle, development, and disease. Critical reading of the literature on chromosome and chromatin biology.

BCH8114 ADVANCED TOPICS IN THE CELL CYCLE (3cr.)
Mechanisms of cell cycle regulation. Model systems critical to deciphering the cell cycle in eukaryotes: budding and fission yeast, Xenopus laevis egg extracts, Aspergillus nidulans, Drosophila melanogaster, sea urchin and mouse oocytes and cultured vertebrate cells. Overview of the prokaryotic cell cycle.

BCH8116 MODEL ORGANISMS AND SYSTEMS BIOLOGY (3cr.)
Utilization of model organisms in the development and advancement of the systems biology field. Particular attention will be paid to the use of organisms such as Saccharomyces cerevisiae as a model platform for cell cycle progression/cancer. Other models may also be included. The basics of the technology will be discussed along with the application of technology to complex biological questions, in particular relating to the cell cycle. Course offered in alternate years.

BCH8117 ADVANCED TOPICS RELATING TO THE CELL CYTOSKELETON AND MEMBRANES (3cr.)
Advanced study of recent literature dealing with the mammalian cellular cytoskeleton and membrane with an emphasis on the regulation of cell motility, adhesion and cell division.

BCH8134 / MIC8134 STRUCTURE AND EXPRESSION OF EUKARYOTIC AND PROKARYOTIC GENOMES (3cr.)
Sequencing of eukaryote and prokaryote genomes with emphasis on recent technologies, sequence alignments and databases and assembly of genomes from massively parallel sequencing data. Focus on mapping studies, including linkage disequilibrium-based genome-wide association study (GWAS), to characterize functional variants associated with complex traits. Analysis and structure of microbial metagenomes from environmental and human habitats, including structure-function analysis of microbial communities, microbiota-human disease correlations, and molecular phylogeny. Genome expression, including measures of RNA transcripts and proteins and statistical analysis of data. Combination of various -omics data to understand gene-environment interactions.

BCH8165 SPECIAL TOPICS IN BIOCHEMISTRY I (2cr.)
A survey of recent advances in selected areas of biochemistry.

BCH8166 SPECIAL TOPICS IN BIOCHEMISTRY II (2cr.)
A survey of recent advances in selected areas of biochemistry.

BCH8310 CURRENT TOPICS IN RNA MOLECULAR BIOLOGY (3cr.)
Properties, mechanisms associated with regulation and the functions of RNAs and Ribonucleoprotein (RNPs) as well as RNA organisms. Current knowledge on RNA expression (synthesis, processing, transport and localization), the structure-function relationship and molecular mechanisms associated with RNAs and RNA genomes, RNA in evolution and in the origin of life, and RNA as therapeutic agents. Prerequisites: BCH/BIO 3570-3170 or equivalent with the permission of the program director. Exclusion : CMM 8310.

BCH8366 PhD SEMINAR (3cr.)
Attendance and participation in the annual BMI Student Symposium and BMI Poster Day, attendance at BMI seminars relevant to Biochemistry. Students will present a poster in their first and every alternate year, and an oral presentation the second and every alternate year until they have permission to write their thesis. Graded S/NS

BCH8511 BIOLOGIE DES CHROMOSOMES ET DE LA CHROMATINE (3cr.)
Organisation de la structure des chromosomes et le remodelage de la chromatine ainsi que l’impact de ceux-ci sur la régulation de l’expression génique, la réplication, la réparation et la recombinaison de l’ADN ainsi que sur la ségrégation des chromosomes. Les modifications histoniques et le positionnement des nucléosomes ainsi que leur influence sur la structure organisée des chromosomes. Importance des chromosomes et de la chromatine dans le contexte du cycle cellulaire, du développement et des maladies. Lecture critique de la littérature portant sur la biologie des chromosomes et de la chromatine.

BCH8534 / MIC 8534 STRUCTURE ET EXPRESSION DES GÉNOMES PROCARYOTES ET EUCARYOTES (3cr.)
Le séquençage des génomes eucaryotes et procaryotes, avec un accent particulier sur les technologies récentes, l’alignement des séquences et les bases de données, et l’assemblage des génomes à partir de données générées par séquençage haut débit. Les études de cartographie comparée incluant les études d’associations pangénomiques basées sur le déséquilibre de liaison pour caractériser les variantes fonctionnelles associées aux traits complexes. L’analyse et la structure de métagénomes microbiens issus d’habitats humains et environnementaux incluant l’analyse structure-fonction des communautés microbiennes, les corrélations entre les maladies humaines et le microbiome ainsi que la phylogénie moléculaire. L’expression génique incluant les mesures de transcriptomes et de protéomes ainsi que l’analyse statistique des données. La combinaison des différentes -données omiques pour comprendre les interactions gène-environnement.

BCH9997 SÉMINAIRE DE RECHERCHE / RESEARCH SEMINAR
À l'intention des étudiants faisant de la recherche en vue de l'obtention du Ph.D. Un séminaire, fondé sur les résultats originaux de leur recherche, doit être présenté par les étudiants avant qu'ils ne commencent à rédiger leur thèse de Ph.D. / For students doing research leading to the doctorate. A seminar, based on the student's original results, to be presented just prior to the writing of the PhD thesis.

BCH9998 EXAMEN DE SYNTHÈSE (DOCTORAT) / COMPREHENSIVE EXAMINATION (PhD)
À l'intention des étudiants inscrits au programme de Ph.D. L'inscription à ce cours est limitée à trois sessions consécutives. / For students enrolled in the doctoral program. Enrollement in this course is limited to three consecutive academic sessions.

BCH9999 RECHERCHE POUR LA THÈSE DE DOCTORAT / DOCTORAL THESIS RESEARCH
À l'intention des étudiants faisant de la recherche en vue de l'obtention du Ph.D. Les étudiants doivent soumettre au Département un plan détaillé de la recherche qu'ils se proposent de faire. Chaque année, une rencontre avec un comité consultatif doit avoir lieu et un rapport de progrès doit être soumis au Département. / For students doing research leading to the doctoral degree. Students are responsible for ensuring that a detailed outline of the proposed research is on file with the Department and that they have an annual meeting with an advisory committee. Yearly progress reports must also be submitted to the Department.

CMM5315 CELLULAR AND MOLECULAR BASIS OF CARDIOVASCULAR FUNCTION/DYSFUNCTION (3cr.)
Mechanism of failing heart and cardiovascular system, its associated functions and associated conditions. Therapies for restoring function. Topics include: regulation of heart development, cell signaling, cellular and molecular mechanisms of atherosclerosis and heart disease, hormonal regulation, hypertension, bioenergetics, cardiovascular genomics and genetics, cell therapy, and regenerative medicine.

MED8166 PROFESSIONALISM AND PROFESSIONAL SKILLS
Basic professional skills related to academic integrity, proper referencing techniques, avoidance of plagiarism, professional etiquette, public speaking, time and stress management, conflict management, teamwork, knowing when and how to access student support services. Compulsory for all students enrolled in master’s or doctoral programs at the Faculty of Medicine. Graded S/NS (Satisfactory/Not satisfactory).

MED8566 ATTITUDE ET COMPÉTENCES PROFESSIONNELLES
Compétences professionnelles de base en matière d’intégrité scolaire, d’usage des références, de vigilance face au plagiat, d’étiquette professionnelle, de présentations orales, de gestion du temps et du stress, de gestion des conflits, de travail d’équipe et de savoir faire à l’égard de l’accès aux services d’appui aux étudiants. Obligatoire pour tous les étudiants inscrits aux programmes de maîtrise ou de doctorat de la Faculté de médecine. Noté S (satisfaisant) ou NS (non satisfaisant).

Quick Picks